Hall, Charlie L., Potticary, Jason, Hamilton, Victoria, Gaisford, Simon, Buanz, Asma ORCID: 0000-0002-2556-1256 and Hall, Simon R. (2020) Metastable crystalline phase formation in deep eutectic systems revealed by simultaneous synchrotron XRD and DSC. Chemical Communications, 56 (73). pp. 10726-10729. ISSN 1359-7345 (Print), 1364-548X (Online) (doi:https://doi.org/10.1039/D0CC04696E)

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Abstract

The phase behaviour of various deep eutectic systems was analysed using concurrent synchrotron powder X-ray diffraction and differential scanning calorimetry. Deep eutectic systems containing the pharmaceuticals metacetamol, 2-ethoxybenzamide or benzamide as binary mixtures with phenol revealed new crystalline phases melting either before or with crystals of phenol, highlighting their lower stabilities. Furthermore, in the phenol:2-ethoxybenzamide system it was shown that multiple metastable phases can form, highlighting the potential for the separation of a hierarchy of crystal structures with differing stabilities from eutectic systems. Through these experiments, we strengthen the idea that eutectic systems can be described by understanding the formation and stabilities of metastable co-crystalline structures. These novel results lead to a deeper understanding of the structure and thermodynamics of deep eutectic solvents, with relevance for analagous systems across materials science.

Item Type:	Article
Additional Information:	Unmapped bibliographic data: M3 - 10.1039/D0CC04696E [Field not mapped to EPrints] JO - Chem. Commun. [Field not mapped to EPrints]
Uncontrolled Keywords:	simultaneous synchrotron XRD and DSC; deep eutectic
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	05 May 2022 11:02
URI:	http://gala.gre.ac.uk/id/eprint/35868

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