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Mitosis inhibitors induce massive accumulation of phytoene in the microalga Dunaliella salina

Mitosis inhibitors induce massive accumulation of phytoene in the microalga Dunaliella salina

Xu, Yanan ORCID: 0000-0002-1697-6070 and Harvey, Patricia ORCID: 0000-0001-7193-4570 (2021) Mitosis inhibitors induce massive accumulation of phytoene in the microalga Dunaliella salina. Marine Drugs, 19 (11):595. ISSN 1660-3397 (Print), 1660-3397 (Online) (doi:https://doi.org/10.3390/md19110595)

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Abstract

Phytoene is a colourless natural carotenoid that absorbs UV light and provides antioxidant and anti-inflammatory activities as well as protection against photodamage. It is therefore valued for its skin health and aesthetic benefits by the cosmetic industry, as well as by the health food sector. The halotolerant green microalga Dunaliella salina is one of the richest sources of natural carotenoids. We have previously investigated the over-production of phytoene in D. salina after cultivation with the well-characterised mitosis inhibitor, chlorpropham. In this study, 15 herbicides with different modes of action were tested for their potential to promote phytoene accumulation. All herbicides showed different levels of capabilities to support phytoene over-production in D. salina. Most significantly, the two mitosis inhibitors tested in this study, propyzamide and chlorpropham, showed similar capacities to support the over-production of phytoene by D. salina cultures as phytoene desaturase inhibitors. The cellular content of phytoene increased by over 10-fold within 48 h of treatment with the mitosis inhibitors compared to untreated cultures. Results indicate a general effect of mitosis inhibitors on phytoene accumulation in D. salina. Furthermore, red light was found to significantly enhance the phytoene yield when used in combination with effective inhibitor treatments. Red light can be applied to maximize the production of phytoene from D. salina.

Item Type: Article
Uncontrolled Keywords: phytoene; Dunaliella salina; mitosis inhibitors; herbicides; red light
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
S Agriculture > SH Aquaculture. Fisheries. Angling
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Algal Biotechnology Research Group
Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Related URLs:
Last Modified: 19 Nov 2021 12:39
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/34415

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