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Kolbe anodic decarboxylation as a green way to access 2-pyrrolidinones

Kolbe anodic decarboxylation as a green way to access 2-pyrrolidinones

Lam, Kevin ORCID: 0000-0003-1481-9212 (2020) Kolbe anodic decarboxylation as a green way to access 2-pyrrolidinones. Organic Letters, 22 (5). pp. 1771-1775. ISSN 1523-7060 (doi:https://doi.org/10.1021/acs.orglett.0c00056)

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Abstract

Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical–radical cross-coupling.

Item Type: Article
Uncontrolled Keywords: Kolbe, nootropic, medchem, pharma
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 13 Aug 2021 15:24
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/33249

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