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Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function

Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function

James, Amy M., Seal, Susan E. ORCID: 0000-0002-3952-1562, Bailey, Andy M. ORCID: 0000-0002-7594-3703 and Foster, Gary D. ORCID: 0000-0002-1979-1397 (2021) Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function. Molecular Plant Pathology, 22 (3). pp. 382-389. ISSN 1464-6722 (Print), 1364-3703 (Online) (doi:https://doi.org/10.1111/mpp.13021)

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Abstract

Plant viruses typically have highly condensed genomes, yet the plant‐pathogenic viruses Cassava brown streak virus, Ugandan cassava brown streak virus, and Euphorbia ringspot virus are unusual in encoding an enzyme not yet found in any other virus, the “house‐cleaning” enzyme inosine triphosphatase. Inosine triphosphatases (ITPases) are highly conserved enzymes that occur in all kingdoms of life and perform a house‐cleaning function by hydrolysing the noncanonical nucleotide inosine triphosphate to inosine monophosphate. The ITPases encoded by cassava brown streak virus and Ugandan cassava brown streak virus have been characterized biochemically and are shown to have typical ITPase activity. However, their biological role in virus infection has yet to be elucidated. Here we review what is known of viral‐encoded ITPases and speculate on potential roles in infection with the aim of generating a greater understanding of cassava brown streak viruses, a group of the world's most devastating viruses.

Item Type: Article
Additional Information: © 2021 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: cassava brown streak disease, Euphorbia ringspot virus, ITPase
Subjects: S Agriculture > S Agriculture (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Last Modified: 15 Mar 2021 22:23
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/31843

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