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Wound dressings as growth factor delivery platforms for chronic wound healing

Wound dressings as growth factor delivery platforms for chronic wound healing

Catanzano, Ovidio, Quaglia, Fabiana and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2021) Wound dressings as growth factor delivery platforms for chronic wound healing. Expert Opinion on Drug Delivery, 18 (6). pp. 737-759. ISSN 1742-5247 (Print), 1744-7593 (Online) (doi:https://doi.org/10.1080/17425247.2021.1867096)

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Abstract

Introduction: Years of tissue engineering research have clearly demonstrated the potential of integrating growth factors (GFs) into scaffolds for tissue regeneration, a concept that has recently been applied to wound dressings. The old concept of wound dressings that only take a passive role in wound healing has now been overtaken, and advanced dressings which can take an active part in wound healing, are of current research interest.

Areas covered: In this review we will focus on the recent strategies for the delivery of GFs to wound sites with an emphasis on the different approaches used to achieve fine tuning of spatial and temporal concentrations to achieve therapeutic efficacy.

Expert opinion: The use of GFs to accelerate wound healing and reduce scar formation is now considered a feasible therapeutic approach in patients with a high risk of infections and complications. The integration of micro – and nanotechnologies into wound dressings could be the key to overcome the inherent instability of GFs and offer adequate control over the release rate. Many investigations have led to encouraging outcomes in various in vitro and in vivo wound models, and it is expected that some of these technologies will satisfy clinical needs and will enter commercialization.

Item Type: Article
Uncontrolled Keywords: wound healing, growth factors, wound dressing, drug delivery, nanotechnologies, chronic wound
Subjects: Q Science > Q Science (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 26 Jul 2021 08:25
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/30593

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