Skip navigation

Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Sarheed, Omar, Shouqair, Douha, Ramesh, KVRNS, Amin, Muhammad, Boateng, Joshua ORCID: 0000-0002-6310-729X and Drechsler, Markus (2020) Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery. Therapeutic Delivery, 11 (11). pp. 685-700. ISSN 2041-5990 (Print), 2041-6008 (Online) (doi:https://doi.org/10.4155/tde-2020-0075)

[img] PDF (Author Accepted Manuscript)
30372 BOATENG_Physicochemical_Characteristics_(AAM)_2020.pdf - Accepted Version
Restricted to Registered users only until 24 November 2021.

Download (379kB) | Request a copy

Abstract

Aim:
To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process.

Results/methodology:
Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine.

Conclusion:
Stable SLNs were successfully prepared by ultrasound-assisted PIT.

Item Type: Article
Uncontrolled Keywords: Franz diffusion cell; permeation; phase inversion temperature; pig skin; solid lipid nanoparticles; synthetic membrane; transdermal
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / School / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 03 Dec 2020 19:12
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/30372

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics