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Iodoform-blended portland cement for dentistry

Iodoform-blended portland cement for dentistry

Qiu, Li, Deacon, Andrew D. and Coleman, Nichola (2020) Iodoform-blended portland cement for dentistry. Prosthesis, 2 (4). pp. 277-296. ISSN 2673-1592 (Online) (doi:

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Portland cement-based formulations blended with radiopacifying agents are popular endodontic materials for various root filling and pulp capping applications. Iodoform (CHI3) is an alternative candidate radiopacifier whose impact on the setting, bioactivity, antimicrobial properties and cytotoxicity of white Portland cement were evaluated in this study. Isothermal conduction calorimetry and 29Si magic angle spinning nuclear magnetic resonance spectroscopy (MAS NMR) showed that 20 wt% iodoform had no significant impact on the kinetics of cement hydration with respect to the formation of the major calcium silicate hydrate (C-S-H) gel product (throughout the 28-day observation). Conversely, transmission electron microscopy demonstrated that iodine was incorporated into the ettringite (Ca₆Al₂(SO₄)₃(OH)₁₂·26H₂O) product phase. Both iodoform-blended and pure Portland cements exhibited comparable biocompatibility with MG63 human osteosarcoma cells and similar bioactivity with respect to the formation of a hydroxyapatite layer upon immersion in simulated body fluid. By virtue of their high alkalinity, both cements inhibited the growth of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. However, in all cases, iodoform enhanced the antimicrobial effect and significantly reduced the minimum bactericidal concentration of the cement. In conclusion, iodoform offers antimicrobial advantages in Portland cement-based formulations where oral biofilm formation threatens the success of root filling materials and dentine substitutes. The reactivity with the calcium aluminosulfate components of the hydrating cement matrix warrants further research to understand the long-term stability of the cement matrix in the presence of iodoform.

Item Type: Article
Additional Information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Uncontrolled Keywords: calcium silicate cement; Portland cement; endodontic bioceramic; cement hydration; iodoform; radiopacifier; magic angle spinning nuclear magnetic resonance spectroscopy; isothermal conduction calorimetry; Fourier transform infrared spectroscopy; antimicrobial
Subjects: Q Science > Q Science (General)
R Medicine > RK Dentistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 13 Oct 2020 18:10

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