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Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Henderson, Scott H., West, Ryan A., Ward, Simon E. and Honey, Mark A. ORCID: 0000-0001-7272-476X (2018) Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science, 5 (6):180333. ISSN 2054-5703 (Online) (doi:https://doi.org/10.1098/rsos.180333)

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Abstract

The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.

Item Type: Article
Uncontrolled Keywords: halodecarboxylation, selective halogenation, mild conditions
Subjects: Q Science > Q Science (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 27 Jul 2020 15:39
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/28918

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