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Decarboxylative bromination of heteroarenes: initial mechanistic insights

Decarboxylative bromination of heteroarenes: initial mechanistic insights

Patel, Pritesh R., Henderson, Scott H., Roe, Mark S. and Honey, Mark A. ORCID: 0000-0001-7272-476X (2020) Decarboxylative bromination of heteroarenes: initial mechanistic insights. Synlett, 31 (16). pp. 1603-1607. ISSN 0936-5214 (Print), 1437-2096 (Online) (doi:https://doi.org/10.1055/s-0040-1707901)

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Abstract

After an initial report from our laboratory describing metal-free decarboxylative halogenation of various azaheteroarenes, we set out to investigate the possible mechanism by which this chemistry occurs. Evidence from this mechanistic investigation suggests that this chemistry occurs via a radical pathway, with 1HNMR studies suggesting the acidic substrates activate NBS.

Item Type: Article
Uncontrolled Keywords: decarboxylation, halogenation, reaction mechanism, bromosuccinimide, azahetarenes
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 18 Jul 2021 01:38
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/28917

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