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Anodic oxidation of dithiane carboxylic acids: a rapid and mild 2 way to access functionalized orthoesters

Anodic oxidation of dithiane carboxylic acids: a rapid and mild 2 way to access functionalized orthoesters

Garcia, Anthony D., Leech, Matthew C., Petti, Alessia, Denis, Camille, Goodall, Iain C. A., Dobbs, Adrian P. ORCID: 0000-0002-7241-7118 and Lam, Kevin ORCID: 0000-0003-1481-9212 (2020) Anodic oxidation of dithiane carboxylic acids: a rapid and mild 2 way to access functionalized orthoesters. Organic Letters, 22 (10). pp. 4000-4005. ISSN 1523-7060 (Print), 1523-7052 (Online) (doi:https://doi.org/10.1021/acs.orglett.0c01324)

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Abstract

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.

Item Type: Article
Uncontrolled Keywords: orthoesters, anodic oxidation, electrochemistry, electrosynthesis
Subjects: Q Science > Q Science (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 27 Apr 2021 01:38
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: REF 2
URI: http://gala.gre.ac.uk/id/eprint/27986

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