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Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences

Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences

El-Betany, Alaa M.M., Kamoun, Elbadawy A., James, Craig, Jangher, Abdulhakim, Aljayyoussi, Ghaith, Griffiths, Peter ORCID: 0000-0002-6686-1271, McKeown, Neil B. and Gumbleton, Mark (2020) Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences. International Journal of Pharmaceutics, 579:119187. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2020.119187)

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Abstract

The epithelial permeation of water-soluble fluorescent PAMAM dendrons based on 7H-benz[de] benzimidazo [2,1-a] isoquinoline-7-one as a fluorescent core across epithelial cell models MDCK I and MDCK II has been quantified.

Hydrodynamic radii have been derived from self-diffusion coefficients obtained via pulsed-gradient spin-echo Nuclear Magnetic Resonance (PGSE-NMR). Results indicate that these dendritic molecules are molecularly disperse, non-aggregating, and only slightly larger than their parent homologues. MDCK I permeability studies across epithelial barriers show that these dendritic molecules are biocompatible with the chosen epithelial in-vitro model and can permeate across MDCK cell monolayers. Permeability is demonstrated to be a property of dendritic size and cell barrier restrictiveness indicating that paracellular mechanisms play the predominant role in the transport of these molecules.

Item Type: Article
Uncontrolled Keywords: diffusion, dendrimers, cell trafficking
Subjects: Q Science > Q Science (General)
R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Materials & Analysis Research Group
Last Modified: 31 Mar 2020 12:02
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF 2020/1: None
URI: http://gala.gre.ac.uk/id/eprint/27296

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