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A novel micro-photogrammetric instrument for visualizing in 3D small objects applied to the quantitative study of the dissolution behavior of a pharmaceutical dosage form

A novel micro-photogrammetric instrument for visualizing in 3D small objects applied to the quantitative study of the dissolution behavior of a pharmaceutical dosage form

D'Angelo, Alessandra, Reading, Mike and Antonijevic, Milan ORCID: 0000-0002-5847-7886 (2019) A novel micro-photogrammetric instrument for visualizing in 3D small objects applied to the quantitative study of the dissolution behavior of a pharmaceutical dosage form. Review of Scientific Instruments, 90 (12):124101. ISSN 0034-6748 (Print), 1089-7623 (Online) (doi:https://doi.org/10.1063/1.5135378)

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Abstract

The work presented here proposes an innovative approach to 3D chemical mapping of solid formulations by micro-photogrammetry. We present details of a novel micro-photogrammetry apparatus and the first results for the application of photogrammetry to the dissolution analysis of solid pharmaceutical dosage forms. Unlike other forms of optical imaging, micro-photogrammetry allows a true 3D model to be con-structed that includes direct observation of the sides of the sample rather than only top-down topographic imaging. Volume and structural changes are assessed quantitatively and related to chemical analysis by high performance liquid chromatography (HPLC). The recently introduce method of chemical identifica-tion by dissolution analysis, or chemical imaging by dissolution analysis (CIDA), is employed for the first time to obtain tomographic images of the dissolution process.

Item Type: Article
Uncontrolled Keywords: chemical imaging by dissolution analysis, micro-photogrametry, tablet dissolution, 3D chemical mapping
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 02 May 2020 12:36
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: REF 5
URI: http://gala.gre.ac.uk/id/eprint/26017

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