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Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs

Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs

Said, Mohamed, Thompson, Elinor ORCID: 0000-0002-6434-9290 and Everett, Jeremy ORCID: 0000-0003-1550-4482 (2019) Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs. In: UK C.elegans meeting, 16th September 2019, Imperial College London, Sir Alexander Fleming Building, Imperial College Rd, London, UK. (Unpublished)

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Assisting healthy ageing is a key goal of 21st-century healthcare. Ageing is “the progressive accumulation of changes with time that are associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age”. Caenorhabditis elegans (C. elegans) is an attractive model species for ageing studies due to its short life cycle (ca 3 days), its rapid development and ageing, and the homology of its genome to that of Homo sapiens. There is a clear link between changes in metabolism and changes in longevity, so metabolic profiling of low molecular weight metabolites (metabonomics) can be used to help understand the nature of ageing and longevity in C. elegans.

FMOs have an important role in ageing and it was recently reported that metabolic ageing was impacted in mice with the enzyme flavin monooxygenase 5 (FMO5) removed by gene knockout (KO). Neuronal stabilization of hypoxia-inducible factor 1 (HIF-1) increases the life span of C. elegans through a cell non-autonomous signal to the intestine resulting in activation of FMO2, so FMOs may play a critical role in promoting health and longevity.

This study uses metabolic profiling to determine the effects of genetic knockout of FMOs on longevity and metabolic ageing in C. elegans. Metabolic profiling of C. elegans wild type and FMO mutants using nuclear magnetic resonance (NMR) was carried out to identify both the differences between different mutants and the metabolites that are linked with long life. Phenotypic studies indicated that some C. elegans FMOs had a role in the ageing and extension of the life span. Preliminary metabolic profiling experiments on different worm extracts observed some metabolic differences between the genotypes, thus indicating that metabonomics is a valuable and effective tool for studying ageing for in the nematode C. elegans.

Item Type: Conference or Conference Paper (Poster)
Uncontrolled Keywords: C. elegans worms, genetic mutants, ageing, NMR, metabolic profiling, metabonomics
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 10 Dec 2019 15:54

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