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Oral thin films as a remedy for non-compliance in paediatric and geriatric patients

Oral thin films as a remedy for non-compliance in paediatric and geriatric patients

Yir-Erong, Bartholomew, Bayor, Marcel T, Ayensu, Isaac, Gbedema, Stephen Y and Boateng, Joshua ORCID: 0000-0002-6310-729X (2019) Oral thin films as a remedy for non-compliance in paediatric and geriatric patients. Therapeutic Delivery, 10 (7). ISSN 2041-5990 (Print), 2041-6008 (Online) (doi:https://doi.org/10.4155/tde-2019-0032)

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Abstract

Pediatric and geriatric patients experience swallowing difficulties for traditional oral dosage forms, such as tablets. Further, microbial contamination, chemical stability, unpleasant taste and swallowing large volumes of fluids have led to low therapeutic efficacy and patient noncompliance. The emergence of oral thin films has resulted in dramatic improvements in compliance and drug therapy outcomes in pediatric and geriatric patients. Oral thin films do not require water for administration, are readily hydrated upon contact with saliva, adhere to the mucosa and disintegrate ideally under 1 min. This article provides an overview of oral thin films, modern trends in their formulation and characterization, available commercial products, information to fill knowledge gaps and future potential and economic prospects of oral thin film technology, with emphasis on their use in the pediatric and geriatric patient groups.

Item Type: Article
Uncontrolled Keywords: emerging technologies, drug delivery, hot melt extrusion, geriatric, paediatric, patient compliance, oral dosage forms, solvent casting, taste masking, thin films
Subjects: R Medicine > R Medicine (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 02 Jul 2020 01:38
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None
URI: http://gala.gre.ac.uk/id/eprint/24752

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