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Inhibition of prandial and waterspray-induced rat grooming by 8-OH-DPAT

Inhibition of prandial and waterspray-induced rat grooming by 8-OH-DPAT

Montgomery, A.M.J. and Hartley, J.E. (2008) Inhibition of prandial and waterspray-induced rat grooming by 8-OH-DPAT. In: Summer Meeting of the British Association for Psychopharmacology 2008, 20-23 Jul 2008, Harrogate, UK.

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In addition to its hyperphagic effect in rats, 8-OH-DPAT also reduces grooming, but it is uncertain whether the inhibition of grooming is a specific effect or a consequence of response competition from eating. The present experiments explored the effects of 8-OH-DPAT on periprandial grooming and grooming elicited by spraying rats with water.
Momentary time sampling over 30 or 60 min, with behaviour scored in one of 6 or 7 (depending on food availability) mutually exclusive categories (feeding, active, scratching, face grooming, body grooming, genital grooming and resting) at 15s intervals, was used for data collection. Non-deprived rats were tested in the presence and absence of food and baseline grooming levels were manipulated by spraying the dorsal surface of the back with water. Data were submitted to ANOVA.
The first experiment confirmed that 8-OH-DPAT increased food intake and that this was associated with a parallel increase in feeding observations; active observations were also increased, but resting and total grooming observations were reduced: scratching was reduced even at 0.003mg/kg, face- and body-grooming were reduced at doses > 0.03mg/kg and genital-grooming was least sensitive, only being reduced at 0.1mg/kg. The second experiment revealed that spraying with water had no effect on food intake, feeding or resting observations, but increased total grooming (largely due to increased body-grooming) and reduced activity observations. In rats sprayed with water, 8-OH-DPAT increased food intake (0.1mg/kg) and observations of feeding (0.003 & 0.1mg/kg), but total grooming was dose-dependently inhibited, with genital-grooming most sensitive(> 0.003mg/kg), followed by face-grooming (> 0.01mg/kg) and body-grooming (>0.03mg/kg), whilst low levels of scratching were unaffected. The final experiment tested water-sprayed rats in the absence of food: 8-OH-DPAT increased resting and reduced total grooming, mostly as a consequence of reductions in face- and body-grooming, but there were also modest reductions in scratching.
These results confirm that 8-OH-DPAT has a suppressant effect on all aspects of grooming, except where there are probable floor effects, and that this is independent of
response competition from increased eating.

Item Type: Conference or Conference Paper (Paper)
Additional Information: [1] This paper (MC08) was presented on Monday 21st July 2008 in the Group C Conference stream, Neuropharmacology 1, within the Summer Meeting of the British Association for Psychopharmacology 2008 held in Harrogate, UK. [2] The abstract for this paper (MC08) appears in the Abstract Supplement to Volume 22 No 5 July 2008 of the Journal of Psychopharmacology on page A26.
Uncontrolled Keywords: 8-OH-DPAT, grooming behaviour, microstructural analysis, obsessive-compulsive disorder, OCD
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RM Therapeutics. Pharmacology
Pre-2014 Departments: School of Health & Social Care
School of Health & Social Care > Department of Psychology & Counselling
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Last Modified: 14 Oct 2016 09:06

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