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Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity

Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity

Loizidou, Eriketi Z. and Zeinalipour-Yazdi, Constantinos D. ORCID: 0000-0002-8388-1549 (2014) Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity. Chemical Biology & Drug Design, 84 (1). pp. 99-107. ISSN 1747-0277 (Print), 1747-0285 (Online) (doi:https://doi.org/10.1111/cbdd.12298)

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Abstract

A computational procedure was developed to study the subunit‐specific interactions of the proteasome inhibitors argyrin A and F, with the aim of indentifying the determinants of subunit selectivity. Three‐dimensional models of humanized proteasome active sites β1, β2 and β5 were developed and subsequently used in molecular docking simulations with the argyrin analogues. The subunit selectivity exhibited by each analogue could be explained based on the site‐specific interactions and a probability‐based specificity parameter derived in this study. A rational approach that involved maximizing site‐specific interactions was followed to guide the design of new argyrin analogues as specific inhibitors of the caspase‐like (β1 site) activity.

Item Type: Article
Uncontrolled Keywords: argyrin analogous, molecular docking, sub-unit specificity, human proteasome
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 06 Oct 2018 03:38
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/21472

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