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Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media

Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media

Loizidou, Eriketi, Zeinalipour-Yazdi, Constantinos ORCID: 0000-0002-8388-1549 and Sun, Lifang (2004) Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media. Biomacromolecules, 5 (5). pp. 1647-1652. ISSN 1525-7797 (Print), 1526-4602 (Online) (doi:https://doi.org/10.1021/bm0497320)

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Abstract

A water-soluble self-associating amphiphilic copolymer was employed to provide a microenvironment for the solvation of a hydrogen-bonding barbiturate artificial receptor, to facilitate molecular recognition in water. The receptor-attached amphiphilic polymer (RP) was synthesized through random copolymerization of 3% (mol) barbiturate receptor-monomer, 70% (mol) 3-sulfopropyl methacrylate, and 27% (mol) n-dodecyl acrylate. Difference UV spectra of pH 6.5 aqueous solutions of phenobarbital and receptor-polymer (RP) gave peaks and valleys at 272 and 301 nm respectively, consistent with binding characteristics of monomeric barbiturate receptors in chloroform. Specific association between phenobarbital and the receptor-polymer was further indicated based on investigations of a receptor-free control polymer (CP) of similar polar/nonpolar monomer ratio. Micellar electrokinetic chromatography was applied for studying polymer-phenobarbital association, by capillary electrophoresis.

Item Type: Article
Uncontrolled Keywords: Artificial receptor-attached amphiphilic copolymer, barbiturate binding, docking simulations
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 07 Oct 2018 01:02
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/21463

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