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Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance

Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance

Loizidou, Eriketi Z., Zeinalipour-Yazdi, Constantinos D. ORCID: 0000-0002-8388-1549, Christofides, Tasos and Kostrikis, Leondios G. (2009) Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance. Bioorganic & medicinal chemistry, 17 (13). pp. 4806-4818. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2009.04.058)

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Abstract

This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine carboxamide families and the most advanced inhibitors Raltegravir and Elvitegravir. Distinct differences were observed in the energetics of binding between the studied classes of inhibitors that also correlated with drug resistant patterns. Quantitative-property–activity-relationships correlated experimental IC50 values to the binding energy and the logarithm of the partition coefficient between n-octanol and water (clog P). The approach followed here serves as an improved basis for the development of ‘second generation’ integrase inhibitors.

Item Type: Article
Uncontrolled Keywords: binding parameters, HIV-1, integrase inhibitors, docking
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 06 Oct 2018 22:32
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/21458

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