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The antibacterial activity and release of quaternary ammonium compounds in an orthodontic primer

The antibacterial activity and release of quaternary ammonium compounds in an orthodontic primer

Ozel, M. B, Tüzüner, T., Güçlü, Z. A., Coleman, N. J., Hurt, A. P. and Buruk, C. K. (2018) The antibacterial activity and release of quaternary ammonium compounds in an orthodontic primer. Acta Odontologica Latinoamerica, 30 (3). pp. 141-148. ISSN 0326-4815 (Print), 1852-4834 (Online)

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Abstract

The aim of this study was to evaluate the impact of 10 wt% benzalkonium chloride (TB-BAC) or 10 wt% cetylpyridinium chloride (TB-CPC) on the antimicrobial properties of the orthodontic adhesive primer, Transbond XT™ (TB). Antimicrobial activity was assessed using a zone of inhibition diffusion test and the release of the antimicrobial compounds was monitored by high performance liquid chromatography (HPLC). Shear bond strength (SBS) was tested using bovine enamel. Control, TB, specimens failed to demonstrate intrinsic antibacterial activity at 1, 7 and 14 days; whereas, TB-BAC and TB-CPC showed antibacterial effects at all times. HPLC analysis indicated no significant differences in the release behaviour of TB-BAC and TB-CPC (t-test, p > 0.05), except for the 7-day release which was higher for TB-BAC (p < 0.05). By 14 days the extents of release were 27 ± 2% and 25 ± 5% of the total initial loading for TB-BAC and TB-CPC, respectively. The incorporation of 10 wt% BAC or CPC in Transbond XT™ adhesive primer also resulted in superior shear bond strength at 7 and 14 days (Fisher’s LSD, p < 0.05) with no significant change in the mode of bracket failure under shear stress (Pearson’s chi-squared, p > 0.05).

Item Type: Article
Uncontrolled Keywords: Antibacterial activity; benzalkonium chloride; cetylpyridinium chloride; orthodontic primer
Subjects: R Medicine > RK Dentistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 19 Jul 2018 15:53
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/20413

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