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Bioactivity and antimicrobial properties of chitosan-tobermorite membranes

Bioactivity and antimicrobial properties of chitosan-tobermorite membranes

Hooper, Gemma, Hurt, Andrew P. and Coleman, Nichola J. (2018) Bioactivity and antimicrobial properties of chitosan-tobermorite membranes. In: UKSB 2018 Annual Meeting, 28th & 29th June 2018, University of Bath, UK. (In Press)

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Abstract

Tobermorite (Ca5Si6O16(OH)2.4H2O) is a layered calcium silicate hydrate phase whose bioactivity and biocompatibility with respect to bone and dental tissues are documented. Chitosan is a biodegradable mucopolysaccharide derivative that has been evaluated as a tissue scaffold material for the in situ regeneration of bone and periodontal structures. Recent studies have shown that tobermorite-chitosan composites are potential candidates for use as biodegradable guided tissue regeneration (GTR) membranes [2,3]. During the GTR process, a membrane is used to isolate the exposed root surface from invasive epithelial and gingival tissues in order to enable the slow-growing periodontal ligament and hard tissues to regenerate. Resistance to potentially pathogenic oral bacteria is a highly desirable property of GTR membranes which are prone to biomaterial-centred infection. Silver (Ag+), copper (Cu2+) and gallium (Ga3+) ions are reported to confer antimicrobial activity when incorporated into bioactive materials [1,4,5]. In the present study, tobermorite was synthesised and ion-exchanged with Ag+, Cu2+ or Ga3+ ions. The in vitro bioactivity and antibacterial properties of solvent-cast tobermorite-chitosan composite membranes were then evaluated with respect to their potential use as GTR membranes to repair damaged periodontal structures.

Item Type: Conference or Conference Paper (Poster)
Uncontrolled Keywords: Guided tissue regeneration, periodontal repair, antimicrobial, copper, silver, zinc
Subjects: R Medicine > RK Dentistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 08 Dec 2018 23:35
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/20411

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