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Synthesis and anodic electrochemistry of cymanquine and related complexes

Synthesis and anodic electrochemistry of cymanquine and related complexes

Lam, Kevin ORCID: 0000-0003-1481-9212 and Geiger, William E. (2016) Synthesis and anodic electrochemistry of cymanquine and related complexes. Journal of Organometallic Chemistry, 817. pp. 15-20. ISSN 0022-328X (doi:https://doi.org/10.1016/j.jorganchem.2016.05.009)

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Abstract

Three compounds have been prepared in which a 4-aminochloroquinoline moiety is covalently linked to a cyclopentadienyl manganese tricarbonyl moiety. One of these ("cymanquine", 4) is the analogue of the potent antimalarial drug ferroquine in which an FeCp group has been replaced by a Mn(CO)3 group. The anodic electrochemistry of the new compounds was investigated in dichloromethane, using NBu4B(C6F5)4 as the supporting electrolyte. Compared to ferroquine, oxidations of the new compounds occur at considerably more positive potentials and are highly irreversible, being located at their amine groups rather than at the organometallic center.

Item Type: Article
Uncontrolled Keywords: Anodic oxidation, Bioorganometallic, Chloroquinoline, Cymantrene, Ferroquine, Weakly coordinating anion
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 04 Dec 2017 10:06
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/17713

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