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Does one bout of high intensity resistance training change circulatory levels of Irisin?

Does one bout of high intensity resistance training change circulatory levels of Irisin?

del Valle, Maria Fernandez, Short, Matthew J., McComb, Jacalyn, Chung, Eunhee, Kloiber, Shelby, Larumbe-Zabala, Eneko and Naclerio, Fernando ORCID: 0000-0001-7405-4894 (2016) Does one bout of high intensity resistance training change circulatory levels of Irisin? Medicine & Science in Sports & Exercise, 48 (5s). p. 864. ISSN 0195-9131 (Print), 1530-0315 (Online) (doi:

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The recently novel identified myokine, irisin, has gained attention as a way to increase energy expenditure by enhancing metabolic function. Exercise and active lifestyle increase the synthesis of contraction-regulated myokines that have direct effect on cells metabolism.

PURPOSE: The objective of this study is to analyze the effects of one bout of high intensity exercise on circulatory levels of irisin in healthy young adults.

METHODS: A total of 24 participants (age 21.3 ± 2.1 years, body mass index [BMI] 22.12 ± 1 kg/m2, lean body mass [LBM] 46 ± 10.1 kg, and relative body fat [%BF] 25.9 ± 9.9) were recruited. Subjects were blocked by sex, BMI, LBM, and %BF content and randomized to either control (n=13) or intervention (n=11). Physical Fitness was assessed by means of dual-energy x-ray absorptiometry (DXA), strength tests (Bench press and Leg press one repetition maximum [1RM]), and cardiopulmonary maximal stress test. Blood samples were collected to assess irisin at baseline, during (45 minutes), and post-intervention.

RESULTS: Irisin (ul/ml) levels for control and intervention groups were 6.1 ± 1.7 and 5.77 ± 0.9 at baseline, 5.6 ± 1.3 and 6.03 ± 1 at 45-min, and 6.3 ± 1.9 and 5.8 ± 1.1 at post respectively. Interaction effect (time x intervention) was close to statistical significance (F[2,44]=3.106, p=0.055), and time (F[2,44]=0.837, p=0.440) and intervention (F[1,22]=0.091, p=0.766) factors were not significant.

CONCLUSIONS: In addition to heterogeneous research findings, the lack of changes on serum concentrations of irisin after intervention shown in this study adds controversial results to the literature. Furthermore, values obtained on irisin concentrations in the control group resulted in more questions rather than answers. We hypothesize that, if irisin is an exercise-induced hormone, other confounding variables such as room temperature, or body temperature might be critical factors to control for future studies.

Item Type: Article
Uncontrolled Keywords: Strength; Power; Fat; Hormone Response
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Exercise Activity and Rehabilitation
Last Modified: 22 Nov 2021 11:49

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