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Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction

Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction

Ferrazzi, Giulio, Murgasova, Maria Kuklisova, Arichi, Tomoki, Malamateniou, Christina, Fox, Matthew J., Makropoulos, Antonios, Allsop, Joanna, Rutherford, Mary, Malik, Shaihan, Aljabar, Paul and Hajnal, Joseph V. (2014) Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction. NeuroImage, 101. pp. 555-568. ISSN 1053-8119 (Print), 1095-9572 (Online) (doi:https://doi.org/10.1016/j.neuroimage.2014.06.074)

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Abstract

There is growing interest in exploring fetal functional brain development, particularly with Resting State fMRI. However, during a typical fMRI acquisition, the womb moves due to maternal respiration and the fetus may perform large-scale and unpredictable movements. Conventional fMRI processing pipelines, which assume that brain movements are infrequent or at least small, are not suitable. Previous published studies have tackled this problem by adopting conventional methods and discarding as much as 40% or more of the acquired data. In this work, we developed and tested a processing framework for fetal Resting State fMRI, capable of correcting gross motion. The method comprises bias field and spin history corrections in the scanner frame of reference, Combined with slice to volume registration and scattered data interpolation to place all data into a consistent anatomical space. The aim is to recover an ordered set of samples suitable for further analysis using standard tools such as Group Independent Component Analysis (Group ICA). We have tested the approach using simulations and in vivo data acquired at 1.5 T. After full motion correction, Group ICA performed on a population of 8 fetuses extracted 20 networks, 6 of which were identified as matching those previously observed in preterm babies.

Item Type: Article
Uncontrolled Keywords: Fetal fMRI; Slice to volume registration; Resting State Networks Scattered interpolation Bias field correction; Spin history correction
Subjects: Q Science > QM Human anatomy
Faculty / Department / Research Group: Faculty of Education & Health
Faculty of Education & Health > Department of Family Care & Mental Health
Faculty of Education & Health > Health & Society Research Group
Last Modified: 02 Jul 2018 11:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: GREAT c
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/16214

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