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Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement

Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement

Coleman, Nichola J., Awosanya, Kunle and Nicholson, John W. (2008) Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement. Journal of Biomedical Materials Research Part A, 90A (1). pp. 166-174. ISSN 1549-3296 (Print), 1552-4965 (Online) (doi:

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In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre-existing Si-OH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo-second-order rate constant for the removal of HPO42- ions frorn solultion has been calculated (k(2) = 5.8 x 10(-4) g mg(-1)). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 166-174, 2009

Item Type: Article
Uncontrolled Keywords: in vitro bioactivity, simulated body fluid, hydroxyapatite, pseudo-second-order kinetic model, portland cement
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 17 Oct 2016 09:09

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