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Modelling the effects of contaminated environments on HFMD infections in mainland China

Modelling the effects of contaminated environments on HFMD infections in mainland China

Wang, Jinyan, Xiao, Yanni and Cheke, Robert ORCID: 0000-0002-7437-1934 (2016) Modelling the effects of contaminated environments on HFMD infections in mainland China. BioSystems, 140. pp. 1-7. ISSN 0303-2647 (Print), 1872-8324 (Online) (doi:https://doi.org/10.1016/j.biosystems.2015.12.001)

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Abstract

Hand-foot-mouth disease (HFMD) has spread widely in mainland China increasing in prevalence in most years with serious consequences for child health. The HFMD virus can survive for a long period outside the host in suitable conditions, and hence contaminated environments may play important roles in HFMD infection. A new mathematical model was proposed and used to investigate the roles that asymptomatic individuals and contaminated environments played in HFMD dynamics. The model includes both direct transmission between susceptible and infected individuals and indirect transmission via free-living infectious unites in the environment. Theoretical analysis shows that the disease goes to extinction if the basic reproduction number is less than unity, whilst otherwise the disease persists. By fitting the proposed model to surveillance data we estimated the basic reproduction number as 1.509. Numerical simulations show that increasing the rate of virus clearance and decreasing transmission rates can delay epidemic outbreaks and weaken the severity of HFMD. Sensitivity analysis indicated that the basic reproduction number is sensitive to the transmission rate induced by asymptomatic infectious individuals and parameters associated with contaminated environments such as the indirect transmission rate, the rate of clearance and the virus shedding rates. This implies that asymptomatic infectious individuals and contaminated environments contribute substantially to new HFMD infections, and so would be targets for effective control measures.

Item Type: Article
Additional Information: Publisher's statement about the uploaded document: "This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain." © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: HFMD, contaminated environment, indirect transmission, uniform persistence
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Last Modified: 13 Jul 2017 14:19
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/14204

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