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Towards a more desirable dry powder inhaler formulation: Large spray-dried mannitol microspheres outperform small microspheres

Towards a more desirable dry powder inhaler formulation: Large spray-dried mannitol microspheres outperform small microspheres

Kaialy, Waseem, Hussain, Tariq, Alhalaweh, Amjad and Nokhodchi, Ali (2014) Towards a more desirable dry powder inhaler formulation: Large spray-dried mannitol microspheres outperform small microspheres. Pharmaceutical Research, 1 (31). pp. 60-76. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:https://doi.org/10.1007/s11095-013-1132-2)

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Abstract

Purpose

To investigate, for the first time, the performance of a dry powder inhaler (DPI, Aerolizer®) in the case of a model drug (i.e. albuterol sulphate) formulated with spray dried mannitol carrier particles with homogeneous shape and solid–state form but different sizes.

Methods

Spray dried mannitol (SDM) particles were characterized in terms of size, surface area, morphology, water content, solid–state, density and electrostatic charge by a novel approach. DPI formulations composed of SDM and albuterol sulphate (AS) were prepared and evaluated in terms of drug content homogeneity and in vitro aerosolization performance.

Results

All SDM particles generated similar fine particle fractions of AS. Formulations consisting of larger SDM particles demonstrated better drug content homogeneity, reduced amounts of drug loss and reduced oropharyngeal deposition. Comparing different SDM products demonstrated that SDM powders with relatively poorer flowability, wider size distributions and higher charge density generated DPI formulations with poorer drug content homogeneity and deposited higher amount of drug on the inhaler, mouthpiece adaptor and throat. DPI formulation total desirability increased linearly with the mean diameter of SDM.

Conclusion

Particle shape and solid–state form of mannitol could dominate over carrier size, bulk density, flowability and charge in terms of determining the aerosolization behaviour of AS formulated with mannitol carrier, at least within the experimental protocols applied in the present study.

Item Type: Article
Uncontrolled Keywords: aerosolization, albuterol sulphate, electrostatic charge, physicochemical properties, spray dried mannitol
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 18 Oct 2016 10:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/13865

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