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Pharmacogenomics and pharmacometabonomics for personalised medicine

Pharmacogenomics and pharmacometabonomics for personalised medicine

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) Pharmacogenomics and pharmacometabonomics for personalised medicine. In: FOCUS 2015: National Meeting of the Association for Clinical Biochemistry & Laboratory Medicine, 8-11 June 2015, Cardiff, Wales.

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Many medicines are ineffective or unsafe in significant portions of their patient populations. A key thrust for 21st Century healthcare is to develop more personalised drug treatments such that patients receive medicines that both efficacious and safe. This paradigm is also known as precision medicine. Current personalised medicine approaches rely heavily on the analysis of the genomes of the patients or the organisms that infect them. However, this approach has had less impact and success than was anticipated. Metabonomics is a new ‘omics science that is concerned with the analysis of metabolite profiles, especially in animal and human biofluids or tissues, and the changes in those metabolite profiles as a result of interventions such as exercise, drug treatment or gene mutation. Interest in metabonomics is very high at present as it is realized that metabolite profiles are influenced not just by genetic factors but also by environmental factors such as nutrition, health status and critically, microbiome composition. Pharmacometabonomics is an even newer development that enables the prediction of the metabolism, safety, efficacy or pharmacokinetics of a drug in an animal or human, based on analysis of pre-dose metabolic profiles. This talk will cover both the origin of pharmacometabonomics and its development and applications in pre-clinical and clinical settings, and will explore its utility in personalized medicine. The importance of environmental factors to personalised medicine will be illustrated.

Item Type: Conference or Conference Paper (Lecture)
Uncontrolled Keywords: Metabonomics, Pharmacometabonomics, FMO5
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
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Last Modified: 17 Oct 2016 09:13

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