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Formulation of water insoluble drugs

Formulation of water insoluble drugs

Trivedi, Vivek ORCID: 0000-0001-9304-9214 (2015) Formulation of water insoluble drugs. In: DSM Formulation Symposium, 10 March 2015, Basel, Switzerland. (Unpublished)

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Poor water solubility and the resulting low oral bioavailability of drugs is one of the major challenges encountered by drug discovery and development scientists. Drug candidates with a solubility of less than 1 μg/ml are considered poorly soluble which show unacceptable bioavailability from conventional dosage forms. Formulation plays a major role in determining the rate and extent of absorption of such drugs. There are a number of formulation strategies that could be used to improve the bioavailability of such drugs, primarily either by increasing the dissolution rate or by presenting the drug in solution. Various approaches to enhance the solubility and dissolution rate of drugs have been already reported e.g. inclusion complexation, colloidal systems, solid lipid nanoparticles and nano-structured lipid carriers etc.

Item Type: Conference or Conference Paper (Lecture)
Uncontrolled Keywords: Formulation, Poorly water soluble drugs, Supercritical processing, Cyclodextrin
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 17 Oct 2016 09:13

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