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Iron bioavailability from commercially available iron supplements

Iron bioavailability from commercially available iron supplements

Christides, Tatiana, Wray, David ORCID: 0000-0002-0799-2730, McBride, Richard, Fairweather, Rose and Sharp, Paul (2015) Iron bioavailability from commercially available iron supplements. European Journal of Nutrition, 54 (8). pp. 1345-1352. ISSN 1436-6207 (Print), 1436-6215 (Online) (doi:

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Purpose: Iron deficiency anaemia (IDA) is a global public health problem. Treatment with the standard of care ferrous iron salts may be poorly tolerated, leading to non-compliance and ineffective correction of IDA. Employing supplements with higher bioavailability might permit lower doses of iron to be used with fewer side effects, thus improving treatment efficacy. Here, we compared the iron bioavailability of ferrous sulphate tablets with alternative commercial iron products, including three liquid-based supplements.

Methods: Iron bioavailability was measured using Caco-2 cells with ferritin formation as a surrogate marker for iron uptake. Statistical analysis was performed using one-way ANOVA followed by either Dunnett’s or Tukey’s multiple comparisons tests.

Results: Spatone Apple® (a naturally iron-rich mineral water with added ascorbate) and Iron Vital F® (a synthetic liquid iron supplement) had the highest iron bioavailability. There was no statistical difference between iron uptake from ferrous sulphate tablets, Spatone® (naturally iron-rich mineral water alone) and Pregnacare Original® (a multimineral/multivitamin tablet).

Conclusion: In our in vitro model, naturally iron-rich mineral waters and synthetic liquid iron formulations have equivalent or better bioavailability compared with ferrous iron sulphate tablets. If these results are confirmed in vivo, this would mean that at-risk groups of IDA could be offered a greater choice of more bioavailable and potentially better tolerated iron preparations.

Item Type: Article
Additional Information: [1] Electronic Supplementary Material: The online version of this article (doi:10.1007/s00394-014-0815-8) contains supplementary material, which is available to authorized users. [2] The final publication is available at Springer via
Uncontrolled Keywords: iron supplements, anaemia, pregnancy, bariatric surgery, micronutrient deficiency, caco-2 cells
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified: 09 Oct 2021 04:45

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