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Antibacterial activity of a chitosan-PVA-Ag+-Tobermorite composite for periodontal repair

Antibacterial activity of a chitosan-PVA-Ag+-Tobermorite composite for periodontal repair

Hurt, Andrew P., Ruiz de Clavijo, Alejandra A., Vine, George J., Coleman, Aimee A. and Coleman, Nichola J. (2014) Antibacterial activity of a chitosan-PVA-Ag+-Tobermorite composite for periodontal repair. Conference Papers in Science, 2014:684352. pp. 1-7. ISSN 2356-6108 (Print), 2356-6094 (Online) (doi:

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A polymer-mineral composite was prepared by solvent casting a mixture of chitosan, poly(vinyl alcohol), and Ag+-exchanged tobermorite in dilute acetic acid and characterised by scanning electron microscopy and Fourier transform infrared spectroscopy. The in vitro bioactivity of the CPTAg membrane was confirmed by the formation of hydroxyapatite on its surface in simulated body fluid. The alkaline dissolution products of the tobermorite lattice buffered the acidic breakdown products of the chitosan polymer and the presence of silver ions resulted in marked antimicrobial action against S. aureus, P. aeruginosa, and E. coli. The in vitro cytocompatibility of the CPTAg membrane was confirmed using MG63 osteosarcoma cells. The findings of this preliminary study have indicated that chitosan-poly(vinyl alcohol)-Ag+-tobermorite composites may be suitable materials for guided tissue regeneration applications.

Item Type: Article
Additional Information: [1] This Conference Paper is based on a presentation given by Andrew P. Hurt at “UK Society for Biomaterials Annual Conference 2013” held from 24 June 2013 to 25 June 2013 in Birmingham, United Kingdom. [2] Copyright: (c) 2014 Andrew P. Hurt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (see [3] Citation: Andrew P. Hurt, Alejandra A. Ruiz de Clavijo, George J. Vine, Aimee A. Coleman, and Nichola J. Coleman, “Antibacterial Activity of a Chitosan-PVA-Ag+-Tobermorite Composite for Periodontal Repair,” Conference Papers in Science, vol. 2014, Article ID 684352, 7 pages, 2014. doi:10.1155/2014/684352
Uncontrolled Keywords: polymer-mineral composite, chitosan-PVA-Ag+-tobermorite composite, periodontal repair, antibacterial activity
Subjects: Q Science > QD Chemistry
R Medicine > RK Dentistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
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Last Modified: 04 Dec 2017 10:34

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