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Nigral dopaminergic cell loss in vitamin E deficient rats

Nigral dopaminergic cell loss in vitamin E deficient rats

Dexter, D. T., Nanayakkara, I., Goss-Sampson, M. A. ORCID: 0000-0002-2662-559X, Muller, D. P., Harding, A. E., Marsden, C. D. and Jenner, P. (1994) Nigral dopaminergic cell loss in vitamin E deficient rats. Neuroreport, 5 (14). pp. 1773-1776. ISSN 0959-4965 (Print), 1473-558X (Online)

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alpha-Tocopherol concentrations in brain were reduced to 3% of control levels in rats fed a vitamin E deficient diet for 52 weeks. Vitamin E deficiency resulted in a 19-33% loss of tyrosine hydroxylase (TH) immunopositive neurones in the substantia nigra, but not in the adjacent ventral tegmental area, compared with controls. Vitamin E deficiency, however, did not reduce striatal dopamine concentrations or turnover. When antioxidant defence mechanisms are defective, as in chronic vitamin E deficiency, the nigrostriatal pathway may be affected by oxidative damage and this may have implications for Parkinson's disease.

Item Type: Article
Uncontrolled Keywords: Vitamin E
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified: 09 Oct 2021 04:46
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
Selected for REF2021: None

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