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Birth-pulse models of Wolbachia-induced cytoplasmic incompatibility in mosquitoes for dengue virus control

Birth-pulse models of Wolbachia-induced cytoplasmic incompatibility in mosquitoes for dengue virus control

Zhang, Xianghong, Tang, Sanyi and Cheke, Robert A. ORCID: 0000-0002-7437-1934 (2015) Birth-pulse models of Wolbachia-induced cytoplasmic incompatibility in mosquitoes for dengue virus control. Nonlinear Analysis: Real World Applications, 22. pp. 236-258. ISSN 1468-1218 (doi:https://doi.org/10.1016/j.nonrwa.2014.09.004)

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Abstract

Dengue fever, which affects more than 50 million people a year, is the most important arboviral disease in tropical countries. Mosquitoes are the principal vectors of the dengue virus but some endosymbiotic Wolbachia bacteria can stop the mosquitoes from reproducing and so interrupt virus transmission. A birth-pulse model of the spread of Wolbachia through a population of mosquitoes, incorporating the effects of cytoplasmic incompatibility (CI) and different density dependent death rate functions, is proposed. Strategies for either eradicating mosquitoes or using population replacement by substituting uninfected mosquitoes with infected ones for dengue virus prevention were modeled. A model with a strong density dependent death function shows that population replacement can be realized if the initial ratio of number of infected to the total number of mosquitoes exceeds a critical value, especially when transmission from mother to offspring is perfect. However, with a weak density dependent death function, population eradication becomes difficult as the system’s solutions are sensitive to initial values. Using numerical methods, it was shown that population eradication may be achieved regardless of the infection ratio only when parameters lie in particular regions and the initial density of uninfected is low enough.

Item Type: Article
Additional Information: [1] Acknowledgments: This work is supported by the National Natural Science Foundation of China (NSFCs, 11171199, 11471201) and by the Fundamental Research Funds for the Central Universities (GK201305010, GK201401004, and S2014YB01).
Uncontrolled Keywords: Dengue fever, Wolbachia, cytoplasmic incompatibility, birth-pulse, strong and weak density dependent death rates
Subjects: Q Science > Q Science (General)
Q Science > QA Mathematics
R Medicine > RA Public aspects of medicine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Natural Resources Institute
Related URLs:
Last Modified: 21 Oct 2016 10:26
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12284

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