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Modelling the regulatory system for diabetes mellitus with a threshold window

Modelling the regulatory system for diabetes mellitus with a threshold window

Yang, Jin, Tang, Sanyi and Cheke, Robert A. ORCID: 0000-0002-7437-1934 (2015) Modelling the regulatory system for diabetes mellitus with a threshold window. Communications in Nonlinear Science and Numerical Simulation, 22 (1-3). pp. 478-491. ISSN 1007-5704 (doi:https://doi.org/10.1016/j.cnsns.2014.08.012)

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Abstract

Piecewise (or non-smooth) glucose-insulin models with threshold windows for type 1 and type 2 diabetes mellitus are proposed and analyzed with a view to improving understanding of the glucose-insulin regulatory system. For glucose-insulin models with a single threshold, the existence and stability of regular, virtual, pseudo-equilibria and tangent points are addressed. Then the relations between regular equilibria and a pseudo-equilibrium are studied. Furthermore, the sufficient and necessary conditions for the global stability of regular equilibria and the pseudo-equilibrium are provided by using qualitative analysis techniques of non-smooth Filippov dynamic systems. Sliding bifurcations related to boundary node bifurcations were investigated with theoretical and numerical techniques, and insulin clinical therapies are discussed. For glucose-insulin models with a threshold window, the effects of glucose thresholds or the widths of threshold windows on the durations of insulin therapy and glucose infusion were addressed. The duration of the effects of an insulin injection is sensitive to the variation of thresholds. Our results indicate that blood glucose level can be maintained within a normal range using piecewise glucose-insulin models with a single threshold or a threshold window. Moreover, our findings suggest that it is critical to individualize insulin therapy for each patient separately, based on initial blood glucose levels.

Item Type: Article
Additional Information: [1] The Author's Accepted Manuscript version is attached to this GALA record. [2] Please cite this article as: Yang, J., Tang, S., Cheke, R.A., Modelling the regulatory system for diabetes mellitus with a threshold window, Communications in Nonlinear Science and Numerical Simulation (2014), doi: http://dx.doi.org/10.1016/j.cnsns.2014.08.012. [3] This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Uncontrolled Keywords: glucose-insulin model, insulin therapy, sliding bifurcation, duration, blood glucose level
Subjects: Q Science > QA Mathematics
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Natural Resources Institute
Related URLs:
Last Modified: 21 Oct 2016 11:30
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12079

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