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Not quite the last word on the Perkin reaction

Not quite the last word on the Perkin reaction

Edwards, Mark, Rourk, Paul M., Riby, Philip G. and Mendham, Andrew P. (2014) Not quite the last word on the Perkin reaction. Tetrahedron, 70 (40). pp. 7245-7252. ISSN 0040-4020 (doi:

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Microwave irradiation does not accelerate the rate of the Perkin reaction carried out under normal atmospheric pressure. Water is an essential yet catalytic reactant for the Perkin reaction to occur. Containment of the Perkin reaction in a sealed vessel improves the yield. Two pressure increases are observed during a 4 h reaction time. An induction period is seen in the Perkin reaction when sodium acetate is used as a base. A re-appraisal of the reaction mechanism is proposed on the basis of these observations. The use of PFA® reaction vessels enables the Perkin reaction to occur under aqueous conditions for around 80 reactions/vessel.

Item Type: Article
Additional Information: [1] Published in Tetrahedron, Volume 70, Issue 40, 7 October 2014 - Special Memorial Issue for Professor Sandy McKillop.
Uncontrolled Keywords: Perkin reaction, microwave, water, PFA vessels, mechanism proposal
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 04 Aug 2017 14:14

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