Items where Author is "Tizzard, Graham J."
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Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)
3-dihydro-2H-indol-2-ones
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
3-Methylidene-Oxindoles
Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (print) 1520-6041 (online) (doi:10.1021/om200278j)
3-triazole-containing hydroxamic acids
Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)
absolute configuration
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid , Muhammad, Palmer , Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)
amides
Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)
anticancer
Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters , 2 (5). pp. 358-362. ISSN 1948-5875 (doi:dx.doi.org/10.1021.ml100295v)
bioinorganic
Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters , 2 (5). pp. 358-362. ISSN 1948-5875 (doi:dx.doi.org/10.1021.ml100295v)
click chemistry
Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)
cyclic di-amino acid peptide
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid , Muhammad, Palmer , Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)
cyclic dipeptide
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)
cyclic dipeptides
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid , Muhammad, Palmer , Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)
cyclisation
Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)
DKP ring conformations
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid , Muhammad, Palmer , Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)
evaluation
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
ferrocene
Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters , 2 (5). pp. 358-362. ISSN 1948-5875 (doi:dx.doi.org/10.1021.ml100295v)
ferrocene-based 1
Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)
HDAC inhibition and activity
Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)
HDAC inhibitor
Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters , 2 (5). pp. 358-362. ISSN 1948-5875 (doi:dx.doi.org/10.1021.ml100295v)
heterocycles
Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)
hydroxamic acid
Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters , 2 (5). pp. 358-362. ISSN 1948-5875 (doi:dx.doi.org/10.1021.ml100295v)
kinase inhibitor
Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (print) 1520-6041 (online) (doi:10.1021/om200278j)
kinase inhibitors
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
metallocene
Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (print) 1520-6041 (online) (doi:10.1021/om200278j)
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
methylidene-1
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
microwaves
Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)
parallel synthesis
Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)
synthesis
Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)
x-ray crystal structure
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid , Muhammad, Palmer , Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)
Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)