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Items where Author is "Ayensu, Isaac"

Items where Author is "Ayensu, Isaac"

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Number of items: 66.

adhesion

Kianfar, Farnoosh, Ayensu, Isaac and Boateng, Joshua S. (2014) Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy, 40 (3). pp. 361-369. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2012.762655)

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

anti-infectives

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

anti-inflammatory

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

BSA

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

buccal

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

buccal delivery

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:10.1016/j.carbpol.2012.04.039)

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2011) Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces, 91. pp. 258-265. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.11.004)

Buccal mucosa

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

buccal mucosa delivery

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

carrageenan

Kianfar, Farnoosh, Ayensu, Isaac and Boateng, Joshua S. (2014) Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy, 40 (3). pp. 361-369. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2012.762655)

Chitosan

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2011) Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces, 91. pp. 258-265. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.11.004)

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

Ayensu, Isaac, Boateng, Joshua and Mitchell, John (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. In: UK PharmSci 2010 The Science of Medicines, 1-3 Sep 2010, Nottingham. UK. (Unpublished)

chitosan films

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

dressing

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

drug delivery systems

Ayensu, Isaac (2012) Development of novel formulations for mucosal delivery of protein based drugs. PhD thesis, University of Greenwich.

drug-delivery

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

Ayensu, Isaac, Boateng, Joshua and Mitchell, John (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. In: UK PharmSci 2010 The Science of Medicines, 1-3 Sep 2010, Nottingham. UK. (Unpublished)

Enzyme inhibitor

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

EpiOral

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

Ether-block-polylactide

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

freeze-drying

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

freeze-drying/lyophilisation

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

FTIR

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

glass transition

Kianfar, Farnoosh, Ayensu, Isaac and Boateng, Joshua S. (2014) Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy, 40 (3). pp. 361-369. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2012.762655)

Insulin

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

lyophilisation

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:10.1016/j.carbpol.2012.04.039)

lyophilised wafers

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2011) Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces, 91. pp. 258-265. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.11.004)

membrane dialysis

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

microgels

Ayensu, Isaac (2012) Development of novel formulations for mucosal delivery of protein based drugs. PhD thesis, University of Greenwich.

mucoadhesion

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:10.1016/j.carbpol.2012.04.039)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2011) Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces, 91. pp. 258-265. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.11.004)

mucoadhesive

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

Ayensu, Isaac, Boateng, Joshua and Mitchell, John (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. In: UK PharmSci 2010 The Science of Medicines, 1-3 Sep 2010, Nottingham. UK. (Unpublished)

nanoparticles

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

peptide delivery

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2013) An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Colloids and Surfaces B: Biointerfaces, 112. pp. 9-15. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.07.019)

Permeation enhancement

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

Poly(ethylene glycol)methyl

Giovino, Concetta, Ayensu, Isaac, Tetteh, John and Boateng, Joshua S. (2012) Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): A potential approach for buccal delivery of macromolecules. International Journal of Pharmaceutics, 428 (1-2). pp. 143-151. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2012.02.035)

protein

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:10.1016/j.carbpol.2012.04.039)

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2011) Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids and Surfaces B: Biointerfaces, 91. pp. 258-265. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2011.11.004)

protein delivery

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. International Journal of Biological Macromolecules, 50 (4). pp. 905-909. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2012.02.014)

swelling

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

swelling capacity

Kianfar, Farnoosh, Ayensu, Isaac and Boateng, Joshua S. (2014) Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy, 40 (3). pp. 361-369. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2012.762655)

thiolated chitosan

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

thiolated-chitosan

Ayensu, Isaac, Mitchell, John C. and Boateng, Joshua S. (2012) In vitro characterisation of chitosan based xerogels for potential buccal delivery of proteins. Carbohydrate Polymers, 89 (3). pp. 935-941. ISSN 0144-8617 (doi:10.1016/j.carbpol.2012.04.039)

wafer

Boateng, Joshua S. and Ayensu, Isaac (2014) Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40 (5). pp. 611-618. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2014.884126)

Kianfar, Farnoosh, Ayensu, Isaac and Boateng, Joshua S. (2014) Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system. Drug Development and Industrial Pharmacy, 40 (3). pp. 361-369. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.3109/03639045.2012.762655)

wafers

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

wound healing

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

X-ray diffractometry

Pawar, Harshavardhan V., Boateng, Joshua S., Ayensu, Isaac and Tetteh, John (2014) Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. Journal of Pharmaceutical Sciences, 103 (6). pp. 1720-1733. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1002/jps.23968)

Xerogel

Boateng, Joshua S., Mitchell, John C., Pawar, Harshavardhan and Ayensu, Isaac (2014) Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Protein & Peptide Letters, 21 (11). pp. 1163-1175. ISSN 0929-8665 (Print), 1875-5305 (Online) (doi:10.2174/0929866521666140805124403)

This list was generated on Mon Jun 25 07:19:21 2018 BST.