1,4-benzodiazepin-2-ones, 1,3,5-benzotriazepines,� atom-economical C–H activation chemistry

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) Methodology issues and design approach of VLE on mathematical concepts acquisition within secondary education in England. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:https://doi.org/10.4155/fmc.10.226)

G-protein coupled receptor antagonists, enzyme inhibitors, anticancer agents, palladacycle complexes, synthesis

Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) 1,4-Benzodiazipine-2-ones in medicinal chemistry. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:https://doi.org/10.4155/fmc.10.226)

amines, microwave,molybdenum, nitroarenes, reductions

Spencer, John, Anjum, Nazira, Patel, Hiren, Rathnam, Rajendra and Verma, Jason (2007) Molybdenum hexacarbonyl and DBU reduction of nitro compounds under microwave irradiation. Synlett, 2007 (16). pp. 2557-2558. ISSN 0936-5214 (doi:https://doi.org/10.1055/s-2007-986628)

amines, reduction, molybdenum, microwave, nitroaromatics

Spencer, John, Rathnam, Rajendra, Patel, Hiren and Anjum, Nazira (2008) Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU. Tetrahedron, 64 (44). pp. 10195-10200. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2008.08.036)

benzodiazepine, C-H activation, palladium, catalysis

Spencer, John, Chowdhry, Babur Z., Mallet, Anthony I., Rathnam, Rajendra P., Adatia, Trushar, Bashall, Alan and Rominger, Frank (2008) C-H activations on a 1H-1,4-benzodiazepin-2(3H)-one template. Tetrahedron, 64 (26). pp. 6082-6089. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2008.01.059)

benzodiazepines, biological analysis, drug testing, cyclic compound,

Rathnam, Rajendra Prasad (2010) Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity. PhD thesis, University of Greenwich.

lysosomal cysteine proteases, bioorganometallic chemistry, breast-cancer, complexes, progression, drugs, pharmaceuticals

Spencer, John, Casini, Angela, Zava, Olivier, Rathnam, Rajendra P., Velhanda, Santosh K., Pfeffer, Michel, Callear, Samantha K., Hursthouse, Michael B. and Dyson, Paul J. (2009) Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton Transactions (48). pp. 10731-10735. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/b912096c)

organometallic chemistry, antitumor-activity, complexes, drugs, precatalysts, inhibitors, palladium, design, agents

Spencer, John, Rathnam, Rajendra P., Montukuri, Mahesh, Kotha, Arun K., Richardson, Simon C.W. ORCID: 0000-0002-7927-0649 , Hazrati, Ali, Hartley, John A., Male, Louise and Hursthouse, Michael B. (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions (22). pp. 4299-4303. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/b819061e)

parallel synthesis, microwaves, benzodiazepines, trypanosoma

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2011.01.010)