Ghanizadeh Tabriz, Atabak, Viegas, Beatriz, Okereke, Michael ORCID: 0000-0002-2104-012X, Uddin, Md Jasim, Arribas Lopez, Elena, Zand Fard, Nazanin ORCID: 0000-0003-2058-2354, Ranatunga, Medhavi, Getti, Giulia ORCID: 0000-0003-1402-8496 and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2022) Evaluation of 3D printability and biocompatibility of microfluidic resin for fabrication of solid microneedles. Micromachines, 13:1368. pp. 1-16. ISSN 2072-666X (Online) (doi:https://doi.org/10.3390/mi13091368)

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Abstract

In this study, we have employed Digital Light Processing (DLP) printing technology for the fabrication of solid microneedle (MN) arrays. Several arrays with various geometries, such as cones, three-sided pyramids and four-sided pyramids, with different height to aspect ratios of 1:1, 2:1 and 3:1, were printed. Post-processing curing optimizations showed that optimal mechanical properties of the photocurable resin were obtained at 40 °C and 60 min. Ex vivo skin studies showed that piercing forces, penetration depth and penetration width were affected by the MN geometry and height to aspect ratio. Cone-shaped MNs required lower applied forces to penetrate skin and showed higher penetration depth with increasing height to aspect ratio, followed by three-sided and four-sided printed arrays. Cytotoxicity studies presented 84% cell viability of human fibroblasts after 2.5 h, suggesting the very good biocompatibility of the photocurable resin. Overall, DLP demonstrated excellent printing capacity and high resolution for a variety of MN designs.

Item Type:	Article
Additional Information:	This article belongs to the Special Issue Advanced Functional Materials and 3D Printing for Tissue Engineering and Drug Delivery Applications.
Uncontrolled Keywords:	3D printing; digital light processing; microneedles; piercing; mechanical properties; biocompatibility
Subjects:	Q Science > Q Science (General) Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Food & Markets Department Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	https://www.mdpi.com/2072-666X/13/9/1368
Last Modified:	05 May 2023 12:34
URI:	http://gala.gre.ac.uk/id/eprint/38549

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