Seddon, James A, Whittaker, Elizabeth, Kampmann, Beate, Lewinsohn, Deborah A, Osman, Muhammad ORCID: 0000-0003-3818-9729, Hesseling, Anneke C, Rustomjee, Roxana and Amanullah, Farhana (2018) The evolving research agenda for paediatric tuberculosis infection. The Lancet Infectious Diseases, 19 (9). e322-e329. ISSN 1473-3099 (Print), 1474-4457 (Online) (doi:https://doi.org/10.1016/S1473-3099(18)30787-4)

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Abstract

There are unique challenges facing the diagnosis and management of tuberculosis infection in children. Following exposure to an infectious tuberculosis case and subsequent infection, children frequently progress to tuberculosis disease more rapidly than adults. Increasingly, investigators recognize the concept of sub clinical disease, an entity referring to early asymptomatic disease. Our understanding of the pathogenesis of tuberculosis in children remains limited but could be improved through animal models, laboratory studies evaluating the responses of blood or respiratory samples to mycobacteria in vitro, as well as evaluating immune responses in children exposed to tuberculosis. Identifying children with sub-clinical disease, at high risk of progression to clinically apparent disease, through biomarker discover, would mean that treatment could be targeted to those most likely to benefit. These studies could be embedded in large observational or interventional cohorts. The optimization and discovery of novel treatments for tuberculosis infection in children need to account for mechanisms of action of tuberculosis drugs as well as child-specific factors including pharmacokinetics and appropriate formulations. In this article we present the result of discussions at a large international meeting and the series of research priorities that were developed.

Item Type:	Article
Uncontrolled Keywords:	paediatric tuberculosis
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > RJ Pediatrics
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	24 Mar 2022 09:07
URI:	http://gala.gre.ac.uk/id/eprint/35547

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