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Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Sarheed, Omar, Shouqair, Douha, Ramesh, KVRNS, Amin, Muhammad, Boateng, Joshua ORCID: 0000-0002-6310-729X and Drechsler, Markus (2020) Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery. Therapeutic Delivery, 11 (11). pp. 685-700. ISSN 2041-5990 (Print), 2041-6008 (Online) (doi:https://doi.org/10.4155/tde-2020-0075)

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Abstract

Aim:
To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process.

Results/methodology:
Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine.

Conclusion:
Stable SLNs were successfully prepared by ultrasound-assisted PIT.

Item Type: Article
Uncontrolled Keywords: Franz diffusion cell; permeation; phase inversion temperature; pig skin; solid lipid nanoparticles; synthetic membrane; transdermal
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Last Modified: 24 Nov 2021 01:38
URI: http://gala.gre.ac.uk/id/eprint/30372

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