Ali, Mohammad Naseem, Edwards, Mark and Nicholson, John W. (2009) Zinc polycarboxylate dental cement for the controlled release of an active organic substance: proof of concept. Journal of Materials Science: Materials in Medicine, 21 (4). pp. 1249-1253. ISSN 0957-4530 (Print), 1573-4838 (Online) (doi:https://doi.org/10.1007/s10856-009-3957-0)

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Abstract

The potential of employing zinc polycarboxylate dental cement as a controlled release material has been studied. Benzalkonium chloride was used as the active ingredient, and incorporated at concentrations of 1, 2 and 3% by mass within the cement. At these levels, there was no observable effect on the speed of setting. Release was followed using an ion-selective electrode to determine changes in chloride ion concentration with time. This technique showed that the additive was released when the cured cement was placed in water, with release occurring by a diffusion mechanism for the first 3 h, but continuing beyond that for up to 1 week. Diffusion coefficients were in the range 5.62 × 10(−6) cm(2) s(−1) (for 1% concentration) to 10.90 × 10(−6) cm(2) s(−1) (for 3% concentration). Up to 3% of the total loading of benzalkonium chloride was released from the zinc polycarboxylate after a week, which is similar to that found in previous studies with glass-ionomer cement. It is concluded that zinc polycarboxylate cement is capable of acting as a useful material for the controlled release of active organic compounds.

Item Type:	Article
Additional Information:	[1] The original publication is available at www.springerlink.com.
Uncontrolled Keywords:	zinc polycarboxylate cement, controlled release material, benzalkonium chloride
Subjects:	R Medicine > RK Dentistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	30 Jan 2020 12:40
URI:	http://gala.gre.ac.uk/id/eprint/2080

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