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Characterization of thermo and pH responsive NIPAM based microgels and their membrane blocking potential

Characterization of thermo and pH responsive NIPAM based microgels and their membrane blocking potential

Mohsen, Reham, Vine, George J., Majcen, Natasa, Alexander, Bruce D, and Snowden, Martin J. (2013) Characterization of thermo and pH responsive NIPAM based microgels and their membrane blocking potential. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 428. pp. 53-59. ISSN 0927-7757 (doi:10.1016/j.colsurfa.2013.03.031)

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Abstract

This work aims to study the behavior of temperature-responsive p(NIPAM) and temperature/pH-responsive p(NIPAM)/acrylic acid (AA) microgels. Three microgels were synthesized using surfactant freeemulsion polymerization technique, these are p(NIPAM), p(NIPAM)-co-AA 95:5% (w/w) and p(NIPAM)-co-AA 90:10% (w/w). Dynamic light scattering was used to study the behavior of diluted microgeldispersions (0.5%, w/w p(NIPAM)), while rheology was used to study the viscosity of 2% (w/w) p(NIPAM)dispersions. The characterization data indicate the swelling/deswelling and flocculation/deflocculationbehavior of the microgels. The conditions required for flocculation were used to test the ability of themicrogel dispersions to block a membrane of pore size 5 �m. In 3 h, p(NIPAM), p(NIPAM) 5% AA (w/w)and p(NIPAM)10% AA (w/w) blocked the membrane (decrease the flow rate) by 96.16, 59.44 and 59.8%respectively. Thus, the controlled flocculation of microgels may be used in applications where pore block-ing is important such as the treatment of dentinal hypersensitivity, given that the VPTT of p(NIPAM) is≈34◦C, which is very close to the human body temperature.

Item Type: Article
Uncontrolled Keywords: colloids, p(NIPAM), acrylic acid, DLS, rheology, particle concentration, membrane blockage
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 06 Dec 2016 12:07
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9875

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