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Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems

Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems

Griffiths, Peter C. ORCID: 0000-0002-6686-1271, Mauro, Nicolo, Murphy, Damien M., Carter, Emma, Richardson, Simon C.W., Dyer, Paul and Ferruti, Paolo (2013) Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromolecular Bioscience, 13 (5). pp. 641-649. ISSN 1616-5187 (Print), 1616-5195 (Online) (doi:10.1002/mabi.201200462)

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Abstract

A series of nanoparticles is prepared via layer-by-layer assembly of oppositely charged, synthetic biocompatible polyamidoamine polymers as potential carriers. Particle size, surface charge and internal chain mobility are quantified as a function of the polymer type and number of layers. The effect of addition of surfactant is examined to simulate the effects of nanoparticle dissolution. The cyctotoxicity of these particles (in epithelia and murine cell lines) are orders of magnitude lower than polyethyleneimine controls. Stable nanoparticles may be prepared from mixtures of strongly, oppositely charged
polymers, but less successfully from weakly charged polymers, and, given their acceptable toxicity characteristics, such modularly designed constructs show promise for drug and gene delivery.

Item Type: Article
Additional Information: [1] First published online: 19 March 2013. [2] Published in print: May 2013.
Uncontrolled Keywords: gene delivery, layer-by-layer assembly, nanoparticles, self-assembly, zeta-potential
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:12
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9698

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