Freeze dried thiolated chitosan formulations for protein delivery via the buccal mucosa
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Boateng, Joshua (2010) Freeze dried thiolated chitosan formulations for protein delivery via the buccal mucosa. In: Journal of Pharmacy and Pharmacology. John Wiley & Sons, S1273-S1273. ISSN 2042-7158
Full text not available from this repository.Abstract
The buccal mucosa has received increased attention in recent years for the delivery of proteins/peptides as an alternative to the currently used parenteral route [1]. Although limited by molecular size, hydrophobicity and low permeability of membranes, thiolated chitosan derivatives have however been identified to deliver proteins/peptides across the buccal mucosa because of their mucoadhesive, penetration enhancing and peptidase inhibition properties [2]. This project aims to develop freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa and to determine the effectiveness of cryoprotection and annealing on the stability of the protein drug.
| Item Type: | Conference Proceedings |
|---|---|
| Title of Proceedings: | Journal of Pharmacy and Pharmacology |
| Additional Information: | [1] This article is published in the journal as 'Special Issue: UK-Pharm Sci 2010. The Science of Medicines' - Abstracts from the UK Conference 1-3 September 2010 |
| Uncontrolled Keywords: | freeze-drying, wafers, thiolated chitosan |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| School / Department / Research Groups: | School of Science School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences |
| Related URLs: | |
| Last Modified: | 23 May 2012 12:56 |
| URI: | http://gala.gre.ac.uk/id/eprint/8278 |
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