Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings
Spencer, John, Baltus, Christine B., Press, Neil J., Harrington, Ross W. and Clegg, William (2011) Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings. Tetrahedron Letters, 52 (31). pp. 3963-3968. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.05.025)Full text not available from this repository.
Boc-protected (piperazin-1-ylmethyl)biaryls have been synthesised from (Boc-piperazin-1-ylmethyl) phenylboronic acid pinacol esters via a microwave-mediated Suzuki–Miyaura coupling with aryl bromides viz. 1-bromo-, 2-, 3- or 4-nitrobenzene or 2-bromo-5-nitropyridine. Judicial removal of the protecting group on the piperazine, or facile reduction of the nitro group on the biaryl system enabled the manipulation of two points of functionality in order to diversify the scope of the resulting biaryl library.
|Uncontrolled Keywords:||Suzuki–Miyaura coupling, biaryl, piperazine, microwave|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
|Faculty / Department / Research Groups:||Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences|
|Last Modified:||07 Dec 2016 14:42|
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