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Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease

Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease

BTG International Limited (2004) Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease. WO2004/100943 A1.

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Abstract

A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a triglyceride oil containing both Ϝ-linolenic acid and linoleic acid residues as triglyceride ester, the ratio of Ϝ-linolenic acid to linoleic acid residues at the sn-2 position of the triglyceride being at least 0.8; the amount of Ϝ -linolenic acid residues at the sn-2 position being at least 18 %, wherein the oil is administered at a dose sufficient to maintain or elevate TGF- β1 levels in the patient at a therapeutic level. Preferably the method is that wherein the therapeutic level is such as to produce a TGF- βl/TNF-α ratio of at least 0.5 in blood of a patient, after 18 months of daily dosing. Preferre oils are Borage or Mucor oils having at least 35 % of the sn-2 position fatty acid residues as Ϝ-linolenic acid.

Item Type: Patent
Additional Information: Publication number WO2004100943 A1 Application number PCT/GB2004/002089
Uncontrolled Keywords: Polyunsaturated fatty acids, treatment of multiple sclerosis
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4329

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