Weinrich, Tobias, Xu, Yanan ORCID: 0000-0002-1697-6070, Wosu, Chiziezi, Harvey, Patricia ORCID: 0000-0001-7193-4570 and Jeffery, Glen (2019) Mitochondrial function, mobility and lifespan are improved in Drosophila melanogaster by extracts of 9-cis-β-Carotene from Dunaliella salina. Marine Drugs, 17 (5). pp. 279-288. ISSN 1660-3397 (Online) (doi:https://doi.org/10.3390/md17050279)

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Abstract

Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9-cis-_-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplementation with 9-cis-_-carotene in ageing Drosophila melanogaster improved mitochondrial function in terms of ATP production and whole-body respiration and extended mean lifespan. It also resulted in improved mobility. These data provide a potential biological rational for the beneficial effects of dietary supplementation with 9-cis-_-carotene. These effects may be based on the maintenance of a sound mitochondrial function.

Item Type:	Article
Additional Information:	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords:	ageing; 9-cis-β-carotene; mitochondrial function; mobility; lifespan; Drosophila melanogaster; microalgae; Dunaliella salina
Subjects:	Q Science > QH Natural history > QH426 Genetics
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Algal Biotechnology Research Group Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	25 May 2020 21:31
URI:	http://gala.gre.ac.uk/id/eprint/24272

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