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Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy

Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy

McAuley, William J., Mader, Kerstin T., Tetteh, John, Lane, Majella E. and Hadgraft, Jonathan (2009) Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy. European Journal of Pharmaceutical Sciences, 38 (4). 378- 383. ISSN 0928-0987 (doi:10.1016/j.ejps.2009.09.002)

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Abstract

Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to simultaneously follow the diffusion of model drugs and solvent across polydimethylsiloxane (silicone) membrane. Three model drugs, cyanophenol (CNP), methyl nicotinate (MN) and butyl paraben (BP) were selected to cover a range of lipophilicities. Isostearyl isostearate (ISIS) was chosen as the solvent because its large molecular weight should facilitate observation of whether the drug molecules are able to diffuse through the membrane independently of the solvent. The diffusion of the three drugs and the solvent was successfully described by a Fickian model. The effects of parameters such as the absorption wavelength used to follow diffusion on the calculated diffusion coefficient were investigated. Absorption wavelength which affects the depth of penetration of the infrared radiation into the membrane did not significantly affect the calculated diffusion coefficient over the wavelength range tested. Each of the model drugs was observed to diffuse independently of the solvent across the membrane. The diffusion of a CNP-ISIS hydrogen bonded complex across the membrane was also monitored. The relative diffusion rates of the solute and solvent across the membrane can largely be accounted for by the molecular size of the permeant.

Item Type: Article
Additional Information: [1] First available online: 9 September 2009. [2] Published in print: 5 November 2009. [3] European Journal of Pharmaceutical Sciences is the official journal of the European Federation for Pharmaceutical Sciences (EUFEPS). [4] Published in European Journal of Pharmaceutical Sciences, (2009), Volume 38, Issue 4, pp. 378–383.
Uncontrolled Keywords: diffusion, solvation, polydimethylsiloxane, penetration enhancement, ATR-FTIR spectroscopy
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 08 Dec 2016 15:53
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2072

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