Skip navigation

Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers

Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers

Ahmed, Asif and Boateng, Joshua (2018) Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers. Therapeutic Delivery, 9 (3). pp. 185-204. ISSN 2041-5990 (Print), 2041-6008 (Online) (doi:10.4155/tde-2017-0104)

[img] PDF (Author Accepted Manuscript)
19239 BOATENG_Calcium_Alginate-Based_Antimicrobial_Film_Dressings_2018.pdf - Accepted Version
Restricted to Repository staff only until 10 February 2019.

Download (1MB)

Abstract

Aim:
Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection.

Results/methodology:
Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Films were transparent, flexible, uniform, with ideal moisture handling, maximum drug release within 90 min, killing bacteria within 24 h and highly biocompatible with human keratinocyte cells.

Conclusion:
The results confirmed successful design of biocompatible dressings effective against Gram-positive and Gram-negative bacteria.

Item Type: Article
Uncontrolled Keywords: antibacterial activity, calcium alginate, chronic wounds, ciprofloxacin, diabetic foot ulcers, glycerol, moisture handling, solvent cast film, wound healing
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 15 Feb 2018 14:39
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/19239

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics