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Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects

Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects

Habtemariam, Solomon (2018) Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects. Molecules, 23 (1):117. ISSN 1420-3049 (doi:10.3390/molecules23010117)

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Abstract

Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse plant-animal interactions. Recent studies have also shown that iridoids and other structurally related monoterpenes display a vast array of pharmacological effects that make them potential modulators of the Alzheimer’s disease (AD). This review critically evaluates the therapeutic potential of these natural products by assessing key in vitro and in vivo data published in the scientific literature. Mechanistic approach of scrutiny addressing their effects in the Alzheimer’s brain including the τ-protein phosphorylation signaling, amyloid beta (Aβ) formation, aggregation, toxicity and clearance along with various effects from antioxidant to antiinflammatory mechanisms are discussed. The drug likeness of these compounds and future prospects to consider in their development as potential leads are addressed.

Item Type: Article
Uncontrolled Keywords: monoterpenes; iridoids; Alzheimer’s disease; amyloid beta; drug likeness; multiple mechanisms
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 25 Jan 2018 15:02
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/18989

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